Combined Use of Intrathecal Opioids and Dexmedetomidine in the Management of Neuropathic Pain
نویسندگان
چکیده
Zoonoses Research Center, *Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Health Policy Research Center, Shiraz University of Medical Sciences, Student Research Committee, Department of Gynecology and Obstetrics, Shiraz University of Medical Sciences, Shiraz, Iran Mohamed Amin Ghobadifar, Farideh Pourghashdar*, Armin Akbarzadeh, and Zahra Mosallanejad
منابع مشابه
The synergistic antinociceptive interactions of morphine and dexmedetomidine in rats with nerve-ligation injury.
BACKGROUND Peripheral nerve injury may result in chronic neuropathic pain, which is characterized by spontaneous pain, hyperalgesia, and allodynia. Intrathecal administration of opioids and α2-adrenoceptor agonists produces spinal analgesia by activation of opioidergic and noradrenergic systems. In our study, we have compared the synergistic antiallodynic interaction and side-effects of intrath...
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Acute postoperative pain in patients with opioid tolerance creates a significant management challenge for anesthesiologists and pain medicine physicians. A multimodal approach is key; however other factors can complicate management such as opioid induced hyperalgesia. We present the case of a patient on large amounts of intrathecal opioids for chronic pain syndrome with opioid induced hyperalge...
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BACKGROUND The use of opioids for the treatment of neuropathic pain remains somewhat controversial, since earlier studies indicate that neuropathic pain is generally less responsive to pure micro-opioid analgesia. A growing body of evidence now suggests that different opioids affect different pain pathways, and emerging data support the possibility of a role for buprenorphine in the management ...
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